Organic Chemistry III(2.0 credits) | |||
| Code | : | 10166 | |
| Course Type | : | Basic Specialized Courses | |
| Class Format | : | Lecture | |
| Course Name | : | Chemistry | |
| Starts 1 | : | 3 Autumn Semester | |
| Elective/Compulsory | : | Elective | |
| Lecturer | : | Jiyoung SHIN Professor | |
| •Course Purpose |
| This course was designed to promote an understanding of organic chemistry and to help students build a logical framework for understanding the principle knowledge. The primary purpose of the course is to master a logical framework for understanding fundamental organic chemistry. The outlines essentially provide the reactions of the organic compounds having critical functional groups, such as hydroxy, carbonyl, and amino groups, as well as their derivatives. Students are expected to understand the organic chemical reactions transforming one functional group into another and solve progression problems based on the knowledge learned through the course contents. |
| •Prerequisite Subjects |
| Fundamentals of Chemistry I and II, and Organic Chemistry I and II |
| •Course Topics |
| Class 1 & 2. Alcohols and Ethers --- Acidity/Basicity of Alcohols; Preparation of Alcohols (Nucleophilic Substitutions (SN1 & SN2), Reduction of Carbonyl Compounds, Hydrolysis of Esters); Reaction of Alcohols (Deprotonation, Substitution, Elimination, Oxidation, Inorganic Ester Formation); Preparation of Ethers (Williamson Ether Synthesis) and Reaction of Ethers.
Class 3. Esters --- Inorganic and Organic Esters; Haloalkane Formation from Alcohols via Inorganic Esters; Reaction of Organic Esters (Hydrolysis, Lactones into Open Chain Esters, Esters into Amides and Alcohols, Reduction). Class 4. Acyl Halide --- Reactivity of Carbonyl Compounds (Leaving Ability of Leaving Groups); Reaction of Acyl Halides (Conversion into Carboxylic acid, Anhydride, Ester, Amide, Ketone, Aldehyde, and Phenylalkanone). Class 5. Aldehydes and Ketones --- Preparations of Aldehydes and Ketones (Oxidation of Alcohols, Ozonolysis of Alkenes, Hydration of Alkynes; Friedel-Grafts Acylation) Class 6. Reactions of Aldehydes and Ketones --- Grignard Reaction; Hydration (in acid/base); Acetalization/Deacetalization; Thioacetalization/Dethioacetalization/Desulfurization. Class 7. Reactions of Aldehydes and Ketones --- Conversions into Cyanohydrin; Wittig Reaction; Baeyer-Villiger Oxidation; Conversion into Imine, Oxime, and Hydrazone; Reduction of Acyl Compounds into Alkanes. Class 8. Assessment of the Classes 1-7 with Practice Problems. Class 9. Enols and Enolates --- Reactivity and Reaction Trends of Carbonyl Compounds in Acid and Base Class 10. Reactivities of Formaldehyde, Aldehydes, and Ketones and Their Reactions --- Reactions with Amines (into Imine, Iminium, and Enamine) and Reaction Comparison; Mannich Reaction. Class 11. Reactions of Conjugated Aldehydes, Ketones, --- Preparation of Conjugated Carbonyl Compounds; 1,2-addition versus 1,4-addition; Soft and Hard Base Nucleophiles; Michael Additions; Robinson Annulation. Class 12. Carboxylic Acids --- Preparation of Carboxylic acids (Alcoholysis, Hydrolysis, Over Oxidation of Primary Alcohols, Reduction of CO2, Conversion of Nitrile into Carboxylic Acid). Class 13. Reactions of Carboxylic Acids --- Hell-Volhard-Zelinsky Bromination; Acyl Chloride Formation; Anhydride Formation; Decarboxylation. Class 14. Intermolecular/Intramolecular Cross Condensations --- Aldol Condensation; Claisen Condensation; Retro-Claisen Condensation; Dieckmann Condensation. Class 15. Assessment of Overall Classes (1-14) with Practice Problems. |
| •Textbook |
| Organic Chemistry: Structure and Function (Eighth Edition), Peter K. Vollhardt and Neil Schore, (W. H. Freeman and Company), New York, 2018, Chapters 8-9, and 17-20. |
| •Additional Reading |
| Organic Chemistry (second edition), Jonathan Clayden, Nick Greeves, and Stuart Warren (Oxford University Press), 2012 ISBN-10:0199270295. |
| •Grade Assessment |
| Examination [total 70%: midterm (30%) and final (40%)] and Assessment of Homework and Attendances (30%): S(x≧90), A(90>x≧80), B(80>x≧70), C(70>x≧60), and F(60>x) for the students who entered earlier than 2020; A+(≧95), A(95>x≧x80), B(80>x≧70), C(70>x≧65), C-(65>x≧60), and F(60＞x) for the students who entered in 2020 or later than 2020. The assessment methods will be reconsidered due to the change of the pandemic condition. |
| •Notes |
| Submission of "Course Withdrawal Request Form is necessary to withdraw the course. The student needs to contact the course instructor when the student wants to withdraw from the course.
In the cases of any unavoidable reasons such as sickness, accident, or no attendance school, the student may get a grade of 'Absent' through the judgment of the course instructor and the student when the student submits a 'Course Withdrawal Request Form' to receive the 'Absent' grade. No submission of sickness/absence reports and lack of attendance score will result in an 'F' grade: It is for the protection of other attendances in the corresponding course from the frequent absences of the specific/uncertain student(s). This assessment can be reconsidered within pandemic conditions where the attendance can be replaced with the submission of assignments. |
| •Contacting Faculty |
| Communication through emails (instructor's e-mail: jyshin321(at)gamil.com) is available. Participants can have lecture material for each class through NUCT. Sudden questions will be given to students during lectures to provide substantial feedback.
Students are recommended to prepare each lecture by reading the corresponding chapters in the textbook and to review it by solving the related homework questions. Each assignment is due by the start of the next class. Late or no submission of the assignment is the deduction point of the grade. |