Organic Chemistry V(2.0 credits) | |||
| Code | : | 10182 | |
| Course Type | : | Specialized Courses | |
| Class Format | : | Lecture | |
| Course Name | : | Chemistry | |
| Starts 1 | : | 3 Autumn Semester | |
| Elective/Compulsory | : | Elective | |
| Lecturer | : | Jiyoung SHIN Professor | |
| •Course Purpose |
| This course was established to learn spectroscopic analysis of organic molecules and how to interpret spectral data. The course begins with theoretical/fundamental knowledge on the chromatographic and spectroscopic techniques (GC, HPLC, NMR, UV, IR, Raman, Mass, and so on) and continues to assignments of organic molecular structures with Spectra-type problems. Furthermore, it covers problem-solving regarding organic reactions to reinforce students’ understanding of molecular structures/reactivities. The participants are expected to solve the progressive problems sequentially. |
| •Prerequisite Subjects |
| Organic chemistry I and II |
| •Course Topics |
| Class 1 & 2. Purification/Separation of Organic Molecules --- Chromatographic Principles and Methods; Gas Chromatography and Liquid Chromatography.
Class 3. Principle of Mass Spectrometry --- Ionization Techniques (EI, CI, FAB, ESI, APCI); Ion Separation Techniques (Magnetic Sector, Quadrupole, Ion Trap, TOF, FT); Fragmentations (Heterolytic and Homolytic Cleavages); Mass Patterns of Isotopes. Class 4. Assignment of Mass Spectra --- Guidelines for predicting prominent EI Spectral peaks for Alcohols, Ethers, Ketones, Carboxylic Acids, Esters, Amines, and Aliphatic Sulfides. Class 5. Vibration Spectroscopy --- FT-IR Absorption Spectroscopy and Raman Spectroscopy; Rayleigh and Stokes/Antistokes lines; Molecular Vibrational Motions; Assignment of IR Spectra of Organic Molecules. Class 6. UV-Vis Absorption Spectroscopy --- Wavenumber & Wavelength; Map of UV/vis absorption spectrometer (Monochromator and Diode-type); Beer-Lambert Law and Molecular Absorption Coefficient; Electron Transitions Involving p/s/n Electrons, Charge-Transfer Electrons, and d/f Electrons; pai-Conjugated Systems; Absorption in the Gaseous States. Class 7. Emission Spectroscopy --- Jablonski Energy Diagram and Electron Spin States; Fluorescence and Phosphorescence; Stokes Shift; Instrumental Outlines; Lifetime Decay Profiles; Quantum Yield; Steady State & Transient Absorption Spectroscopy. Class 8 & 9. Fundamental Principle of NMR Spectroscopy --- NMR Active/Inactive Nuclei; External Magnetic Field, Larmor Frequency, Resonance Feature, Saturation, and Net Magnetization, 90 Degree Pulse, Spin-Spin Decay, FT of FID, Structure of NMR Machine, Chemical Shift, Shielding/Deshielding, J coupling; Karplus Curve for Vicinal Couplings and Cis/Trans Correlation; Shimming; Probe Tuning; Locking; Important Parameters for NMR Analysis. Class 10. Characterization of Molecular Structure and Assignment of NMR Spectra, and Advanced Techniques --- Peak Assignments of NMR Spectra of Example Organic Compounds (1H, COSY, NOESY, ROESY, APT 13C, HSQC, HMBC, TOCSY NMR Spectra); NMR Spectra of Paramagnetic Metal Complex. Class 11. Students’ Presentation and Discussion (Assessment of the Classes 1-10). Classes 12-14. Problem-Solving Process for Structure Determination and the Corresponding Organic Reaction. Class 15. Course Assessment and Solution Steps. |
| •Textbook |
| - Organic Chemistry: Structure and Function (Eighth Edition), Peter K. Vollhardt and Neil Schore, (W. H. Freeman and Company), New York, 2018, Chapters 10-21.
- Handout materials of the lectures will be given in the respective classes. |
| •Additional Reading |
| 1. Spectrometric Identification of Organic Compounds (8th Edition), Robert M. Silverstein, Francis X. Webster, David J. Kiemle, and David L. Bryce, (Wiley), 2012, ISBN-10:0470616377.
2. Spectroscopic Methods in Organic Chemistry (2nd Edition) Manfred Hesse, Herbert Meier, Bernd Zeeh (Translated by Richard Dunmur, Martin Myrray), Thieme, New York, ISBN 978-1-58890-488-1. |
| •Grade Assessment |
| Examination [total 70%: midterm (30%) and final (40%)] and Assessment of Homework and attendances (30%): S(x90), A(90>x80), B(80>x70), C(70>x60), and F(60>x) for the students who entered earlier than 2020; A+(95), A(95>xx80), B(80>x70), C(70>x65), C-(65>x60), and F(60x) for the students who entered in 2020 or later than 2020. |
| •Notes |
| Submission of the "Course Withdrawal Request Form is necessary to withdraw the course. The student needs to contact the course instructor when the student wants to withdraw from the course. In the cases of any unavoidable reasons such as sickness, accident, or no attendance school, the student may get a grade of 'Absent' through the judgment of the course instructor and the student when the student submits a 'Course Withdrawal Request Form' to receive the 'Absent' grade. No submission of sickness/absence reports and lack of attendance score will result in an 'F' grade: It is for the protection of other attendances in the corresponding course from the frequent absences of the specific/uncertain student(s).
The course schedule can be reconsidered within pandemic conditions. |
| •Contacting Faculty |
| Students can communicate with the course instructor face-to-face, either in the class or through the appointment. Communication through emails is also available (instructor's e-mail: jyshin321(at)gamil.com).
Lecture material for each class will be provided through NUCT. Students are recommended to review the lectures by solving the related homework questions. Each assignment is due by the start of the next class if it is not specially announced. Sudden questions can be given to students during lectures to provide substantial feedback. |