Organic Chemistry V(2.0 credits)
|Course Type||:||Specialized Courses|
|Starts 1||:||3 Autumn Semester|
|Lecturer||:||Jiyoung SHIN Designated Professor|
|The primary purpose of the course is to learn the spectroscopic analysis of organic molecules and the interpretation of the spectral data. The course begins with theoretical/fundamental knowledge on the chromatographic and spectroscopic techniques (GC, HPLC, NMR, UV, IR, Raman, Mass, and so on) and continues to assignments of organic molecular structures with Spectra-type problems. Furthermore, it covers problem-solving regarding organic reactions to reinforce students’ understanding of the molecular structures/reactivities. The participants are expected to solve the progressive problems sequentially.|
|Organic chemistries I-II|
|Class 1 & 2. Purification/Separation of Organic Molecules --- Chromatographic Principles and Methods; Gas Chromatography and Liquid Chromatography.
Class 3. Principle of Mass Spectrometry --- Ionization Techniques (EI, CI, FAB, ESI, APCI); Ion Separation Techniques (Magnetic Sector, Quadrupole, Ion Trap, TOF, FT); Fragmentations (Heterolytic and Homolytic Cleavages); Mass Patterns of Isotopes.
Class 4. Assignment of Mass Spectra --- Guidelines for predicting prominent EI Spectra peaks for Alcohols, Ethers, Ketones, Carboxylic Acids, Carboxylic Esters, Amines, and Aliphatic Sulfides.
Class 5. Vibration Spectroscopy --- FT-IR Absorption Spectroscopy and Raman Spectroscopy; Rayleigh and Stokes/Antistokes lines; Molecular Vibrational Motions; Assignment of IR Spectra of Organic Molecules.
Class 6. UV-Vis Absorption Spectroscopy --- Wavenumber & Wavelength; Map of UV/vis absorption spectrometer (Monochromator and Diode type); Beer-Lambert Law and Molecular Absorption Coefficient; Electron Transitions Involving p/s/n Electrons, Charge-Transfer Electrons, and d/f Electrons; pai-Conjugated Systems; Absorption in the Gaseous States.
Class 7. Emission Spectroscopy --- Jablonski Energy Diagram and Electron Spin States; Fluorescence and Phosphorescence; Stokes Shift; Instrumental Outlines; Lifetime Decay Profiles; Quantum Yield; Steady State & Transient Absorption Spectroscopy.
Class 8 & 9. Fundamental Principle of NMR Spectroscopy --- NMR Active/Inactive Nuclei; External Magnetic Field, Larmor Frequency, Resonance Feature, Saturation, and Net Magnetization, 90 Degree Pulse, Spin-Spin Decay, FT of FID, Structure of NMR Machine, Chemical Shift, Shielding/Deshielding, J coupling; Karplus Curve for Vicinal Couplings and Cis/Trans Correlation; Shimming; Probe Tuning; Locking; Important Parameters for NMR Analysis.
Class 10. Characterization of Molecular Structure and Assignment of NMR Spectra, and Advanced Techniques --- Peak Assignments of NMR Spectra of Example Organic Compounds (1H, COSY, NOESY, ROESY, APT 13C, HSQC, HMBC, TOCSY NMR Spectra); NMR Spectra of Paramagnetic Metal Complex.
Class 11. Students’ Presentation and Discussion (Assessment of the Classes 1-10).
Class 12. Problem-Solving Process for Structure Determination and the Corresponding Organic Reaction.
Class 13. Problem-Solving Process for Structure Determination and the Corresponding Organic Reaction.
Class 14. Problem-Solving Process for Structure Determination and the Corresponding Organic Reaction.
Class 15. Course Assessment and Solution Steps.
|- Organic Chemistry: Structure and Function (Seventh Edition), Peter C. Vollhardt and Neil E. Schore, (W. H. Freeman and Company), New York, 2014, Chapters 10-21.
- Handout materials of the lectures will be given in the respective classes.
|1. Spectrometric Identification of Organic Compounds (8th Edition), Robert M. Silverstein, Francis X. Webster, David J. Kiemle, and David L. Bryce, (Wiley), 2012, ISBN-10:0470616377.
2. Spectroscopic Methods in Organic Chemistry (2nd Edition) Manfred Hesse, Herbert Meier, Bernd Zeeh (Translated by Richard Dunmur, Martin Myrray), Thieme, New York, ISBN 978-1-58890-488-1.
|Examination (final: 40%) and Presentation (30%) as well as Assessment of Homework (30%): Credits will be awarded to those students who score 60 or more.
Grades are as follows: S(x≧90), A(90>x≧80), B(80>x≧70), C(70>x≧60), and F(60>x).
This condition can be reconsidered following the pandemic condition.
|Submission of "Course Withdrawal Request Form is necessary to withdraw the course. The student needs to contact the course instructor when the student wants to withdraw from the course.
In the cases of any unavoidable reasons such as sickness, accident, or no attendance school, the student may get a grade of 'Absent' through the judgment of the course instructor and the student when the student submits a 'Course Withdrawal Request Form' to receive the 'Absent' grade. No submission of sickness/absence reports and lack of attendance score will result in an 'F' grade: It is for the protection of other attendances in the corresponding course from the frequent absences of the specific/uncertain student(s).
This assessment can be reconsidered within pandemic conditions where the attendance can be replaced with the submission of assignments.
|Communication through emails (instructor's e-mail: firstname.lastname@example.org and email@example.com) is available.
Students are recommended to review the lectures by solving the related homework questions. Each assignment is due by the start of the next class if it is not specially announced.